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Wednesday 25 February 2015

New hidden features of IOS 8

Our collection of hidden and undocumented features found in iOS 8, which was released on September 17 See our iOS 8 Summary of official functions.

FEATURES INCLUDE
Credit Card Scanning Safari
Using the stack App
Wi-Fi Calling
Camera Mode Time-Lapse
Hide Pictures in Photos App

If our greatest asset in August raid IOS focuses on major changes announced by Apple, this iOS 8 raid highlights some of the most interesting new features and improvements, but less mobile operating system from Apple around the beta testing period.

Apple released iOS 8 to the public on September 17, 2014, two days before the launch of iPhone 6 and 6 Plus. Before the public launch, the software went through five betas to developers before a master of gold was released on September 9.

The current version of iOS 8 is iOS 8.1.3, a minor update released on January 27 with several bug fixes and performance improvements. Before iOS 8.1.3, Apple released iOS 8.1 with new features like SMS payment Apple and transfer calls. Apple has seeded iOS 8.2 beta for multiple developers, the SDK WatchKit and some other bug fixes. iOS 8.2 could be released in March. iOS 8.3, which adds features like wireless CarPlay and a new emoji selector is also in development.

Tuesday 24 February 2015

Panobinostat - Get Approval by FDA for the treatment of Relapsed Multiple Myeloma

        The US FDA recently gave approval for Panobinostat for the treatment of Relapsed Multiple Myeloma. Previously in 2014 it was rejected by FDA Oncologic Drugs Advisory Committee  due to its adverse effects. After rejection the manufacturers again submitted additional information to FDA about drug.

      By studying all the information FDA approves Panobinostat.  It is approved to use along with bortezomib and dexamethasone. It is effective in the treatment of Relapsed multiple myeloma in patients who received bortezomab for past 2 years. It is the new class of agents that acts as histone deacetylase inhibitor.

Mechanism of Action of Panobinostat


       It is having new mechanism of action than other cancer agents as histone deacetylase inhibition makes this drug attractive among other cancer drugs. The safety and efficacy data of Panobinostat is based on the clinical study on 193 patients who had received prior treatment with bortezomib and immuno modulatory agents. The clinical phase used is phase 3, randomized,double blind,placebo controlled, multicenter global registration trail. This drug is having several adverse effects which make it rejection by FDA previously.

Adverse effects:
The common adverse effects are,
1. Nausea
2. Vomiting
3. Diarrhoea and
4. Fatigue.

        The most common side effects of this drug in clinical trails are diarrhea, fatigue, nausea, peripheral edema, decreased appetite, pyrexia, and vomiting, with the most common nonhematologic laboratory abnormalities.

Panobinostat capsules


         Common hematologic abnormalities include thrombocytopenia, lymphopenia, leukopenia,neutropenia and anemia. The serious side effect include cardiac toxicity and severe diarrhoea.

So, the patients who receiving panobinostat had to monitor for the adverse effects especially for anemia.

Sunday 15 February 2015

Ovarian cancer risk may increased by Hormone Replacement Therapy

         
           At menopause stage the women bodies stop producing sex hormones (estrogen,progesterone) which are important to maintain normal physiological functions like metabolism,mental activities etc., So after menopause (at post menopausal stage) woman starts to take Estrogen and progesterone pills under the super vision of gynecologist. This is called as Hormone Replacement Therapy (HRT) .

     HRT therapy having some side effects. These are common and mild in nature like dizziness,weight gain,mood swings etc., Recent studies reveal that long term use of HRT may increase the risk of ovarian cancer. The researchers conducted epidemiological studies at U.S by using case and control group and concluded that HRT may increases cancer risk.

            It is very severe in the patients in whom ovaries are dissected at the time of hysterectomy. But risk is lesser in patients with ovaries. The researchers conduct case control study in which, 
1.case group is Patients are post menopausal and having ovarian cancer
2. Control group is patients are postmenopausal but not having ovarian cancer and still having their ovaries.

            They compare both groups by conducting meta-analysis and concluded that the usage of HRT for even less period may increases the cancer risk up to 20% . The researchers also told that patient related factors like body weight,hysterectomy, other diseases does not shows effect on HRT. The more the recent the therapy the great the risk. Woman who had stopped HRT recently but were within 5 years of last use at the time of their cancer risk , although having used HRT for at least 5 years was still associated with 10% increased relative risk more than 5 years later.

Ways to avoid Adverse effects of HRT :
There are some ways to relief from the side effects of HRT. If we follow these we can get rid of side effects. They are, 
1. Yoga
2. Aerobics
3. Healthy food
4. Daily exercises
5. Meditation etc.,


HRT Pill






  

Friday 6 February 2015

New FDA Clearance for Ranibizumab for Diabetic Retinopathy with DME

    
     The USFDA has expanded sate use of Ranibizumab for diabetic retinopathy ane Diabetic Macular Edema (DME) treatment. Diabetes is one of the deadly disease that affecting millions of people every year world wide. In this disease the sugar levels of blood will changes time to time with our order. The patient looses body sugars in urine which makes fall down of sugar levels.


    At the time of eating body sugar levels will increases suddenly which damages body organs. Diabetic patients are more prone to organ damages. The main organ is eye. Several diabetic patients are suffering with diabetic retinopathy which impairs vision. So it needs proper treatment. Organ failure chances will increase with age. It is the most common diabetic eye disease and is leading cause of blindness in adults in US.
Diabetic retinopathy

 
   The present drug Ranibizumab is the first significant therapy to treat diabetic retinopathy and diabetic macular edema.

Safety and Efficacy studies of Ranibizumab:
   This profile is obtained by 2 clinical studies involving 759 participants who were treaed and followed for 3 years. In the two studies, treatment with Ranibizumabled to significant improvement in severity of DME and diabetic retinopathy when compared with the patients who does not receiving the drug.

Side effects:
1. Bleeding of conjuctiva
2. Eye pain
3. Floaters
4. Increased IOP(Intra Occular Pressure)
5. Endophthalmitis and retinal detatchment (Serious)

Ranibizumab

    Previously FDA had approved ranibizumab to treat DME and macular edema secondary to retinal vein occlusions, both of which cause fluid to leak into the macula result in blurred vision. Recently FDA granted the Ranibizumab for diabetic retinopathy with DME and reviewed this new use for the drug under the agency's priority review program, which provides for an expedited review of drugs. This drug provides safe and effective treatment in serious condition.

Route of administration:
Ranibizumab is administered by IV injection once monthly.



Other uses of Ranibizumab:
It is also approved for the treatment of neovascular (wet) age related macular degeneratin in US.